What is the King of Anti-Ageing supplements?

The Anti-Ageing supplement market was valued at $1.4 billion in 2022 and expected to grow to around $3.5 billion by 2033, so longevity is obviously gaining a lot of interest and more innovative products will no doubt be developed over the coming years.

Saying that, could we all simply take a pill or a variety of nutrients and/or lifestyle adaptations and automatically turn on the fountain of youth, becoming Benjamin Button or Peter Pan in the process?

The early adopters that utilise the already vast array of “Anti-Ageing” supplements are in many ways looking for proactive methods to keep a
youthful appearance both externally and more importantly internally, which still funnily seems to be overlooked.

How can Muhdo Health help?

Over the course of the last 7 years Muhdo Health have identified key supplements, nutrients, and lifestyle interventions from 1000’s of time stamped and series epigenetic samples, as well as real time health and fitness data which have shown clear correlations for their positive effect on reducing biological age.

We analysed specific CpG sites on a group of the most important and researched genes such as ELOVL2, OTUD7A, DNAH9 that have shown robustness to intervention and have methylation patterns associated with ageing, these sites hyper/hypo methylate with age and are very stable in this pattern.

A cohort of 260, 30–50-year-olds (chronological age), 120 females and 140 males who do not take, or have not taken any supplements within the last 10 years. Against the same chronological age group of subjects that take as a singular supplement (for 12w or over):

The aim was to see if any of the supplements made an impact (positive of negative) on methylation on of these sites and therefore true ageing against those who take no supplements.

Results

No supplement showed a negative trend.

In order of significance.

1.  Methylfolate – significant positive change
2. Vitamin D3 – positive change
3. Omega-3 – positive change
4. Ashwagandha – positive change
5. NAC – no change
6. CoQ10 – no change
7. MethylB12 – no change
8. Resveratrol – no change

It is important to note that whilst 4 supplements indicated no change this is only on the sites analysed, which are tightly correlated to ageing/time.

They may have greater effects on disease sites or sites for performance etc.  If, however, “anti-ageing” is the main goal it seems prudent to consider, Methylfolate, D3, Omega-3 and Ashwagandha in your anti-ageing routine.