Sleep and Ageing

What actually happens whilst we sleep that enhances everything that we do and becomes some kind of elixir to our health and longevity?

Muhdo Health have been analysing the data from 1000s of people. Then using this data to show lifestyle interventions that may increase longevity and reduce pathology risk through the power of genotyping and DNA methylation.

The following looks at the average sleep data on 475 individuals and how sleep patterns correlate with the biological clock (epigenetic clock) as measured through 400~ CG sites across genes affecting longevity and other metrics. (Data sets on request).

Quality sleep of less than 4 hours per night

> Increases biological age on average 2.2 years.
> Increases the expression of the gene FTO which may increase obesity risk (AVE 0.7 on 3 sites)
> Negatively alters the methylation on genes associated with dementia.
> Correlates with perceived increased daily anxiety.
> Decreased protein synthesis
> Increases inflammation (cytokine encoding gene expression)

Quality sleep of 4 – 6 hours per night

> No significant impact on biological age
> Increases the expression of the gene FTO which may increase obesity risk (AVE 0.58 on 3 sites)
> Negatively alters the methylation on genes associated with dementia.
> Does not correlate with perceived increased daily anxiety.
> Increased protein synthesis
> No effect on inflammation (cytokine encoding gene expression)

Quality sleep of 6 – 8 hours per night

> Decelerated biological age on average -1.6 years.
> No altered expression on FTO
> No effect on dementia genes
> Does not correlate with perceived increased daily anxiety.
> Increased protein synthesis
> No effect on inflammation (cytokine encoding gene expression)

Quality sleep of 8+ hours per night

> No significant impact on biological age
> No altered expression on FTO
> No effect on dementia genes
> Does not correlate with perceived increased daily anxiety.
> Increased protein synthesis
> No effect on inflammation (cytokine encoding gene expression)