𝗧𝗵𝗲 𝗦𝘂𝗻𝘀𝗵𝗶𝗻𝗲 𝗩𝗶𝘁𝗮𝗺𝗶𝗻 𝘁𝗵𝗮𝘁 𝗦𝗹𝗼𝘄𝘀 𝗔𝗴𝗲𝗶𝗻𝗴!

Vitamin D, the “sunshine vitamin,” is vital for calcium regulation, bone health, immune function, and cellular repair.

After synthesis or ingestion, vitamin D is converted in the liver to 25(OH)D and in the kidneys to its active form, 1,25(OH)2D, regulating around 900 genes or 1/24 of your entire genome tied to immune response, DNA repair, cardiovascular health, and longevity (so fairly important we are sure you will agree)

𝗚𝗲𝗻𝗲𝘁𝗶𝗰 𝗥𝗲𝗴𝘂𝗹𝗮𝘁𝗶𝗼𝗻 𝗮𝗻𝗱 𝗩𝗶𝘁𝗮𝗺𝗶𝗻 𝗗 𝗠𝗲𝘁𝗮𝗯𝗼𝗹𝗶𝘀𝗺

Vitamin D’s effectiveness is influenced by genes like CYP2R1 (liver
hydroxylation), CYP27B1 (kidney conversion), and VDR (cellular response).

Variations in these genes and others, such as GC and DHCR7, affect vitamin
D metabolism, transport, and synthesis, making genetic testing fairly useful
for you to understand if you might have a few issues metabolising it
efficiently.

𝗪𝗵𝗮𝘁 𝗵𝗮𝘃𝗲 Muhdo Health 𝘀𝗲𝗲𝗻?

Well over the course of the last 8 years and well over 65,000 DNA and epigenetic samples later we have seen that a daily usage of vitamin D3 from a variety of dosages for >=3 years affects biological ageing.

This data has been summarised and tested through the Muhdo DNA methylation (methylpace*) especially when the gene GPR158 is dysfunctional.

Stats:

No supplements containing D3 = variable ageing -5 years to + 12 years (N=1100) mean +3.2years.

Vitamin D3 taken for a minimum of 3 years = variable ageing -8 years to +11years (N=321) mean -0.8years.

So, this highlights how consistent supplementation over at least a 3-year period showed a reduction in your biological age by nearly 1 years and well on your way to becoming Peter Pan!?

*Methylpace is an algorithm on DNA methylation that predicts age to 89% accuracy with no other inputs besides saliva.

Vitamin D plays a critical role in ageing pathways, supporting genomic stability, reducing inflammation, enhancing mitochondrial function, and maintaining tissue health.

It also influences circadian rhythms and cellular integrity, making it essential for healthy ageing and disease prevention.