𝐋𝐚𝐭𝐞 𝐧𝐢𝐠𝐡𝐭𝐬 𝐰𝐢𝐥𝐥 𝐚𝐠𝐞 𝐲𝐨𝐮 𝐭𝐡𝐞 𝐟𝐚𝐬𝐭𝐞𝐬𝐭!!

Getting a good night’s sleep this year might be something to prioritise as poor sleep quality is one of the main factors for accelerating ageing.

Ageing can be categorised into two types: intrinsic and extrinsic. Intrinsic ageing is driven by genetic factors, while extrinsic ageing is influenced by the lifestyle choices we make each day, such as having a glass or 2 of wine in the evening, smoking, poor diet, limited exercise, and being stressed on a daily basis.

Muhdo Health specialise in longevity and regenerative health. We work with a whole variety of people, from companies to international athletes to optimise their health by addressing these extrinsic factors.

From our experience and reinforced by the epigenetic DNA methylation data that we have seen below, inadequate sleep stands out as the most significant factor that can speed up the ageing process.

We have been analysing the data from 1000s of people over the last 8 years. Then using this data to show lifestyle interventions that may increase longevity and reduce pathology risk through the power of genotyping and DNA methylation.

The following looks at the average sleep data on 348 individuals and how sleep patterns correlate with the biological clock (epigenetic clock) as measured through 400~ CG sites across genes affecting longevity and other metrics.

Quality sleep of less than 4 hours per night

> Increases biological age on average 2.2 years
> Increases the expression of the gene FTO which may increase obesity risk (AVE 0.7 on 3 sites)
> Negatively alters the methylation on genes associated with dementia
> Correlates with perceived increased daily anxiety
> Decreased protein synthesis
> Increases inflammation (cytokine encoding gene expression)

Quality sleep of 4 – 6 hours per night

> No significant impact on biological age
> Increases the expression of the gene FTO which may increase obesity risk (AVE 0.58 on 3 sites)
> Negatively alters the methylation on genes associated with dementia
> Does not correlate with perceived increased daily anxiety
> Increased protein synthesis
> No effect on inflammation (cytokine encoding gene expression)

Quality sleep of 6 – 8 hours per night

> Decelerated biological age on average -1.6 years.
> No altered expression on FTO
> No effect on dementia genes
> Does not correlate with perceived increased daily anxiety
> Increased protein synthesis
> No effect on inflammation (cytokine encoding gene expression)

Quality sleep of 8+ hours per night

> No significant impact on biological age
> No altered expression on FTO
> No effect on dementia genes
> Does not correlate with perceived increased daily anxiety
> Increased protein synthesis
> No effect on inflammation (cytokine encoding gene expression)