Vitamin D, the “sunshine 🌤️ vitamin,” is vital for calcium regulation, bone health🦴, immune 🦠function, and cellular repair.
After synthesis or ingestion, vitamin D 🌤️ is converted in the liver to 25(OH)D and in the kidneys to its active form, 1,25(OH)2D, regulating around 900 genes🧬 or 1/24 of your entire genome tied to immune 🦠 response, DNA repair, 🧬cardiovascular health, and longevity 👵🏽(so fairly important we are sure you will agree)
𝗚𝗲𝗻𝗲𝘁𝗶𝗰 𝗥𝗲𝗴𝘂𝗹𝗮𝘁𝗶𝗼𝗻 🧬 𝗮𝗻𝗱 𝗩𝗶𝘁𝗮𝗺𝗶𝗻 𝗗 𝗠𝗲𝘁𝗮𝗯𝗼𝗹𝗶𝘀𝗺🌤️
Vitamin D’s 🌤️effectiveness is influenced by genes 🧬like CYP2R1 (liver
hydroxylation), CYP27B1 (kidney conversion), and VDR (cellular response).
Variations in these genes 🧬and others, such as GC and DHCR7, affect vitamin
D 🌤️metabolism, transport, and synthesis, making genetic testing fairly useful
for you to understand if you might have a few issues metabolising it
efficiently.
𝗪𝗵𝗮𝘁 𝗵𝗮𝘃𝗲 Muhdo Health 𝘀𝗲𝗲𝗻?🧬
Well over the course of the last 8 years and well over 65,000 DNA and epigenetic 🧬samples later we have seen that a daily usage of vitamin D3 🌤️💊from a variety of dosages for >=3 years affects biological ageing.👵🏽
This data has been summarised and tested through the Muhdo DNA 🧬methylation (methylpace*) especially when the gene GPR158 is dysfunctional.
Stats:
No supplements 💊 containing D3 = variable ageing -5 years to + 12 years 👵🏽(N=1100) mean +3.2years.
Vitamin D3 🌤️💊taken for a minimum of 3 years = variable ageing -8 years to +11years (N=321) mean -0.8years.
So, this highlights how consistent supplementation 💊over at least a 3-year period showed a reduction in your biological age by nearly 1 years and well on your way to becoming Peter Pan!? 🧚🏻🧚🏻
*Methylpace is an algorithm on DNA methylation 🧬that predicts age to 89% accuracy with no other inputs besides saliva.
Vitamin D 🌤️plays a critical role in ageing 👵🏽 pathways, supporting genomic stability🧬, reducing inflammation🔥, enhancing mitochondrial function, and maintaining tissue health.
It also influences circadian rhythms 😴and cellular integrity, making it essential for healthy ageing 👵🏽💪🏽and disease prevention.