𝐓𝐡𝐢𝐬 𝐜𝐨𝐮𝐥𝐝 𝐛𝐞 𝐭𝐡𝐞 𝐍𝐨. 1 𝐦𝐢𝐬𝐭𝐚𝐤𝐞 𝐭𝐡𝐚𝐭 𝐰𝐢𝐥𝐥 ‘𝐦𝐚𝐤𝐞 𝐲𝐨𝐮 𝐚𝐠𝐞 𝐟𝐚𝐬𝐭𝐞𝐫’.☠️☠️

While ageing is not fully understood, it can be broken down into two categories: intrinsic and extrinsic.

Intrinsic ageing is due to certain genetic 🧬factors, while extrinsic ageing can be attributed to lifestyle choices like having a glass of wine 🍷each night, smoking, eating a certain type of diet🥑, if you exercise🏋️‍♀️, as well as managing your stress levels 🤯and getting a good night’s sleep!😴

As an Epigenetics and in many ways longevity company, Muhdo Health helps you to understand your genetic traits 🧬and the way certain genes and longevity pathways are expressing, thus allowing you to improve your health 🍎❤️through tweaking specific extrinsic factors.

Sleep and Ageing 😴

What actually happens whilst we sleep 😴that enhances everything that we do, and becomes some kind of elixir 🧪to our health and longevity?

Muhdo Health has been analysing the data from 1000s of people. Then this data to show lifestyle interventions that may increase longevity and reduce pathology risk through the power of genotyping 🧬 and DNA methylation.

The following looks at the average sleep 😴data on 1128 individuals and how sleep patterns correlate with the biological clock (epigenetic clock) as measured through 400~ CG sites across genes 🧬affecting longevity and other metrics.

Quality sleep of less than 4 hours per night 🥱

> Increases biological age on average 2.2 years.
> Increases the expression of the gene FTO 🧬which may increase obesity risk (AVE 0.7 on 3 sites)
> Negatively alters the methylation on genes associated with dementia. 🧠
> Correlates with perceived increased daily anxiety. 🥲
> Decreased protein synthesis
> Increases inflammation 🔥(cytokine encoding gene expression)

Quality sleep of 4 – 6 hours per night 🥱

> No significant effect on biological age
> Increases the expression of the gene FTO 🧬which may increase obesity risk (AVE 0.58 on 3 sites)
> Negatively alters the methylation on genes associated with dementia. 🧠
> Does not correlate with perceived increased daily anxiety. 🥲
> Increased protein synthesis
> No effect on inflammation 🔥(cytokine encoding gene expression)

Quality sleep of 6 – 8 hours per night 😴

> Decelerated biological age on average -1.6 years.
> No altered expression on FTO
> No effect on dementia 🧠genes
> Does not correlate with perceived increased daily anxiety. 🥲
> Increased protein synthesis
> No effect on inflammation 🔥(cytokine encoding gene expression)

Quality sleep of 8+ hours per night 😴

> No significant effect on biological age
> No altered expression on FTO
> No effect on dementia 🧠genes
> Does not correlate with perceived increased daily anxiety. 🥲
> Increased protein synthesis
> No effect on inflammation 🔥(cytokine encoding gene expression)