𝐋𝐚𝐭𝐞 𝐧𝐢𝐠𝐡𝐭𝐬 😴𝐰𝐢𝐥𝐥 𝐚𝐠𝐞 𝐲𝐨𝐮 𝐭𝐡𝐞 𝐟𝐚𝐬𝐭𝐞𝐬𝐭!! – Muhdo


Getting a good night’s sleep 😴this year might be something to prioritise as poor sleep quality is one of the main factors for accelerating 👵🏽ageing.

Ageing 👵🏽can be categorised into two types: intrinsic and extrinsic. Intrinsic ageing is driven by genetic 🧬factors, while extrinsic ageing is influenced by the lifestyle choices we make each day, such as having a glass or 2 of wine 🍷in the evening, smoking, poor diet🍔, limited exercise🏋️‍♂️, and being stressed 🤯on a daily basis.

Muhdo Health specialise in longevity and regenerative health. We work with a whole variety of people, from companies to international 🏋️‍♂️athletes to optimise their health by addressing these extrinsic factors.

From our experience and reinforced by the epigenetic 🧬DNA methylation data that we have seen below, inadequate sleep 😴stands out as the most significant factor that can speed up the ageing process.👵🏽

We have been analysing the data from 1000s of people over the last 8 years. Then using this data to show lifestyle interventions that may increase longevity and reduce pathology risk through the power of genotyping and DNA 🧬methylation.

The following looks at the average sleep 😴data on 348 individuals and how sleep patterns correlate with the biological clock (epigenetic clock) as measured through 400~ CG sites across genes 🧬affecting longevity and other metrics.

Quality sleep of less than 4 hours per night😴

> Increases biological age on average 2.2 years
> Increases the expression of the gene FTO 🧬which may increase obesity risk (AVE 0.7 on 3 sites)
> Negatively alters the methylation on genes associated with dementia🧠
> Correlates with perceived increased daily anxiety🥲
> Decreased protein synthesis
> Increases inflammation 🔥(cytokine encoding gene expression)

Quality sleep of 4 – 6 hours per night😴

> No significant impact on biological age
> Increases the expression of the gene FTO 🧬which may increase obesity risk (AVE 0.58 on 3 sites)
> Negatively alters the methylation on genes associated with dementia🧠
> Does not correlate with perceived increased daily anxiety🥲
> Increased protein synthesis
> No effect on inflammation 🔥(cytokine encoding gene expression)

Quality sleep of 6 – 8 hours per night😴

> Decelerated biological age on average -1.6 years.
> No altered expression on FTO
> No effect on dementia 🧠genes
> Does not correlate with perceived increased daily anxiety🥲
> Increased protein synthesis
> No effect on inflammation 🔥(cytokine encoding gene expression)

Quality sleep of 8+ hours per night

> No significant impact on biological age
> No altered expression on FTO
> No effect on dementia 🧠genes
> Does not correlate with perceived increased daily anxiety🥲
> Increased protein synthesis
> No effect on inflammation 🔥(cytokine encoding gene expression)

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