Today we will be looking at mental health and as to whether anxiety 🤯🥲 does in fact accelerate the ageing process.
This is another unique finding by the team at Muhdo Health and a bit of a world first, as we have combined DNA 🧬 methylation with genotype COMT rs4680, which is associated with neurotransmitters such as
dopamine and serotonin.
Does anxiety 🤯🥲 cause you to age faster? And does having a certain genotype🧬 accelerate this process further still?
Well unfortunately the answer is a resounding Yes.✅✅
But we didn’t just analyse their DNA 🧬 methylation we also analysed numerous genotypes associated with neurotransmitters 🧠 such as serotonin.
Whilst many didn’t have much correlation to ageing, one did. The rs4680 genotype 🧬 (COMT), is linked with dopamine, with AA homozygotes being linked with higher dopamine and bigger “highs 😁 and lows”. 🥲
𝐑𝐞𝐩𝐨𝐫𝐭𝐞𝐝 𝐀𝐧𝐱𝐢𝐞𝐭𝐲 🤯🥲
Those who reported suffering anxiety 🤯🥲 had an accelerated biological age on average of 4.38 years but only if they were AA in rs4680. 🧬
Those who reported suffering anxiety 🤯🥲 had an accelerated biological age on average of 1.7 years if they were the more common AG genotype 🧬 in rs4680 or GG in the rs4680.
𝐃𝐢𝐝𝐧’𝐭 𝐑𝐞𝐩𝐨𝐫𝐭 𝐀𝐧𝐱𝐢𝐞𝐭𝐲 😁
Those who didn’t report anxiety 😁 with AA in rs4680 🧬had a non-significant change in biological age (0.4).
Those who didn’t report anxiety 😁 with AG/GG in rs4680 🧬 had a deceleration in biological age of -2.2 years.
𝐖𝐡𝐚𝐭 𝐜𝐨𝐮𝐥𝐝 𝐭𝐡𝐢𝐬 𝐚𝐥𝐥 𝐦𝐞𝐚𝐧?🤔
It appears that anxiety 🤯🥲 causes an acceleration in biological ageing and as the genes 🧬analysed for biological age affect cancer🏥, dementia 🧠 and inflammation 🔥it can be said that anxiety 🤯🥲has a foundational physical effect on the body which may lead to serious physical pathology if left untreated.
Having certain genotypes 🧬 may hasten the effect that anxiety 🤯🥲has on the physical self or/and having certain genotypes 🧬protect 🛡️against the physical effects of anxiety.🤯🥲
The above information is just a snippet taken from the vast amount of genomic, 🧬 epigenomic, and lifestyle data gathered during Muhdo Health’s research 📚over the last 8 years.